Color II

General information

COLOR II - A randomized clinical trial comparing laparoscopic and open surgery for rectal cancer.

Dear Madam, Sir,

Your treating surgeon informed you about the COLOR II trial both in oral and writing. This website is an addition to the information already provided.

The safety and short-term benefits of keyhole surgery for colorectal cancer have been debatable. Minimally invasive surgery for cancer reduces surgical trauma but there has been concern that it could lead to tumour recurrence. Despite reduced illness and improved convalescence after keyhole surgery for benign disorders such as gallbladder stones, surgeons have been sceptical about similar advantages of the technique for cancer.

In 1997 the COLOR trial started to include patients in a randomized clinical setting to compare laparoscopic and open surgery in the treatment of colonic cancer. 29 Hospitals from 8 different countries in Europe participated. Around March 2003 the last of 1248 patients entered the study. Short term results were published in the Lancet Oncology of July 2005. As the 3 year follow-up of all patients will end in March 2006, the analysis of data will commence.

Current trial
In 2004, the COLOR II trial was setup to compare laparosopic and open surgery in the treatment of rectal cancer. Till date 22 hospitals from 6 countries in Europe, the United States and Canada include patients in the trial.

More information
By clicking the documents button above, you'll be able to download various trial documents on different subjects. If you still have questions please feel free to contact the trial coordinator by clicking the contact button above.

With kind regards,

Karen Inglis, RN
Trial coordinator COLOR II